Synergy between CD8 T cells and Th1 or Th2 polarised CD4 T cells for adoptive immunotherapy of brain tumours.

The results indicate the same highly significant (P<0.001) accumulation of Th1 cells as found in the short term homing assay.

also in 83,176 other papers

Th1 polarised SMARTA cells were characterised by significantly higher CXCR3 and lower CCR4 expression than Th2 polarised cells; CD49d expression was also higher in Th1 polarised cells, although this did not reach statistical significance ( Figure 1C, D ).

also in 75,281 other papers

It should be noted that in vivo, with co-transfer of CD8 T cells (plus any endogenous type 1 immune cells), there is likely to be significant IFN-γ available to potentially reproduce the cytokine balance we created in vitro.

also in 993 other papers