Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder.

Mol Autism · 2013 · PMC3665583 · PMID 23697635

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nominally significantno p-value reported

A case–control association analysis of individuals with Asperger syndrome ( n = 174) revealed regions in 14 genes, including CYP19A1 , that showed a nominally significant association with Asperger syndrome [ 85 ].

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highly significantno p-value reported

Gene ontology analysis of this complete list of genes using DAVID Bioinformatics Resources 6.7 shows that neuron differentiation and development as well as axonogenesis are significantly over-represented among biological processes shown in Annotation cluster 1 which has a highly significant Enrichment Score (ES) of 5.107 (Table 1 ).

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