[ 27 ] evaluating the prognostic impact of CEA in resectable NSCLC patients failed to reach statistical significance, importantly, they had an overrepresentation of patients with squamous-cell carcinoma (46% overall).
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Usefulness of serum carcinoembryonic antigen (CEA) in evaluating response to chemotherapy in patients with advanced non small-cell lung cancer: a prospective cohort study.
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They also found a difference regarding histology subtype, showing a significant association between adenocarcinoma OR by RECIST and CEA-response which was only barely significant with the squamous histology.