Both in paediatric and adult clinical trials, a positive trend has been found in terms of overall reduction of infection rates and duration, beneficial effect on symptoms, reduction in antibiotics use and possibility to improve the patient's quality of life in several diseases.
2
—
—
The sentences
Concerning the prevention of exacerbations, the data were globally heterogeneous and the difference between active bacterial lysates and placebo did not reach statistical significance, but the metanalysis also showed a shorter duration of exacerbations in the active treated group and the improvement of respiratory symptoms, as assessed both by patients and physicians.