Role of warm ischemia on innate and adaptive responses in a preclinical renal auto-transplanted porcine model.

While in WI or CS group they appear inhibited or reduced, we showed a trend towards increased for TGFβ and a significant rise of its first downstream mediator pSmad3 in WI + CS, indicate a maintain production of collagen and a progression of renal fibrosis accentuated by MMP-2 decrease expression supporting a less extracellular matrix degradation.

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