Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease.

Lipids Health Dis · 2013 · PMC3668217 · PMID 23659495

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borderline significanceno p-value reported

In agreement with our results, 22:6ChE was reported to be increased in forebrains of mutated APP/presenilin-1 mice (11-fold, p < 0.01) and mutated APP mice (3-fold, borderline significance), but not of presenilin-1 mice (0.9-fold) at 9–11.5 months of ages, compared with wild-type mice [ 9 ].

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did not reach statistical significanceno p-value reported

The levels of sarkosyl-insoluble tau appeared to be slightly higher at 10 and 15 months than at 4 months, but these differences did not reach statistical significance among all ages tested.

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