Optimal timing of surgery after neoadjuvant chemoradiation therapy in locally advanced rectal cancer.

Although statistical significance was not reached, our findings showed a trend towards decreased postoperative complication rate in patients operated on ≥8 weeks after CRT (group A, 28.6% vs. group B, 14.6%, P = 0.069).

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[ 11 ] compared short (within 2 weeks) and long (6 to 8 weeks) interval groups following preoperative radiotherapy (RT) and showed that the longer interval was associated with better clinical tumor response, pathological downstaging, and a nonsignificant trend towards increased sphincter preservation.

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