Barely Significant
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Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis.

Arthritis Res Ther · 2013 · PMC3672719 · PMID 23305385

Europe PMCDOI
1
hedged sentence
0.0700
closest p · 1.4× alpha
0.0700
boldest claim

The sentences

did not reach statistical significanceP = 0.07so close (0.05 < p ≤ 0.1)
Although the associations did not reach statistical significance, a larger proportion of patients with high estrone levels (42%) had gastrointestinal involvement compared with those patients with low estrone levels (17%, P = 0.07).

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