Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models.

NVP-BEZ235- and control-treated mice had similar numbers of lesions; significantly fewer metastases were evident in dovitinib-treated mice, while for the combination treatment the P -value approached significance ( n = 5, P < 0.06) (Figure 2C ).

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Testing the pan-ErbB inhibitor AEE788 [ 11 ] in the 4T1 and 67NR models revealed that only the combination of AEE788 and dovitinib resulted in blockade of the FRS2/Erk and PI3K/Akt/mTOR pathways, high levels of apoptosis with prolonged tumor stasis, and in the 4T1 model a highly significant decrease in lung metastasis.

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