Sexually dimorphic SNPs could either show (i) concordant effect direction (CED), if the association is present in one sex ( P-men or P-women at 5% FDR) and at least nominally significant and directionally concordant in the other ( P-women or P-men <0.05, respectively), (ii) single sex effect (SSE), if the association is present in one sex and not significant in the other, or (iii) opposite effect direction (OED), if the association is present in one sex and at least nominally significant in the opposite direction in the other sex.
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Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
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