A review of potassium channels in bipolar disorder.

They first extracted nominally significant signals ( p <0.05) from three GWAS studies (WTCCC, German, and NIMH GAIN datasets; Fangerau et al., 2004 ; Wellcome Trust Case Control Consortium, 2007 ; Baum et al., 2008 ), and prioritized potential candidates based on independent, converging lines of evidence from various bioinformatics resources.

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Since only four genes overlap in the gene sets between samples, it appears that the shared molecular function (mediation of voltage-gated ion channel activity) rather than a few highly significant results common across studies drove the results.

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