Barely Significant
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Synthesis of functionalized spiro[indoline-3,4'-pyridines] and spiro[indoline-3,4'-pyridinones] via one-pot four-component reactions.

Beilstein J Org Chem · 2013 · PMC3678513 · PMID 23766799

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quite significantno p-value reported
The potential uses of this reaction in synthetic and medicinal chemistry may be quite significant.

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