a strong trendp = 0.063
At the 100 ms ISI, there was a strong trend for reduced sensitivity to the disruptive effects of AMPH in METH-treated mice of both sexes (Figures 3C,D , AMPH × METH treatment interaction p = 0.063).
At the 100 ms ISI, there was a strong trend for reduced sensitivity to the disruptive effects of AMPH in METH-treated mice of both sexes (Figures 3C,D , AMPH × METH treatment interaction p = 0.063).
Given that these same pathways are thought to contribute to the expression of positive symptoms in schizophrenia, this work suggests that there may be significant sex differences in the pathophysiology underlying these symptoms.