Genetic contribution and associated pathophysiology in end-stage renal disease.

36 The heritability or the proportion of variation in Gd-IgA1 that is attributable to genetic factors was highly significant.

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Markers on chromosome 10q spanning the homologous region of the rodent Rf-1 gene did not show evidence for linkage with ESRD; however, two adjacent markers on chromosome 10p approached significance in sib pairs with nondiabetic ESRD. 134 In other samples, evidence of linkage approached significance for the gene coding for TGF-β2 133 and evidence of statistically significant association was found for alleles at the plasma kallikrein gene 135 However, the most direct evidence of renal failure susceptibility genes comes from studies of the fawn-hooded rat. 136 Two genes, designated Rf-1 and Rf-2 , were determined to contribute substantially to the development of renal impairment.

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