Three findings from our data support this hypothesis: 1) DRB1*15 is associated with OCB+; 2) the combination of non-HLA markers associated with MS susceptibility also showed a trend for association with the presence of OCB as suggested by our wGRS, although most of its predictive power comes from DRB1*15; 3) after meta-analysis of the Italian best associated markers with two independent data-sets, we found a non-HLA SNP on chromosome 6 that almost reached GWAS significance.
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Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients.
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