Effects of gene regulatory reprogramming on gene expression in human and mouse developing hearts.

The presence of another mouse enhancer in the locus (clustered) mitigates the impact on the gene expression level upon a loss of a heart enhancer ( figure 7 c ), but the qualitative observations did not reach statistical significance in our analysis owing to the low fraction of class II and class III mouse counterparts featuring another mouse heart enhancer in the locus ( figure 7 a ).

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