Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis.

Of particular note is that the body weight difference is highly significant even at 4 weeks of age (WT = 74.2±2.4 grams; KO = 86.4±3.0 grams).

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The average number of interferon-γ producing cells was however noticeably elevated in un-stimulated LRRK2 KO rats compared to the wild type (1710±617 compared to 305±120), though this did not reach statistical significance ( Figure 4D ).

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