Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.

Additionally, H460 IID10 had an increased mean cell volume and showed a trend towards decreased plating efficiency as well as decreased colony radius, possibly due to the detachment of cells from the colonies.

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Notably, both HK2 siRNA transfected ADPGK -null cell lines showed an additional highly significant ∼4-fold loss of clonogenicity ( Figure 5D ), with no further change in colony size, compared to WT also treated with HK2 siRNA.

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Two days after transfection with control siRNA, cell numbers of knockout clones were not significantly different from WT, although a small trend towards reduced proliferation was noted for H460 IID10 as above ( Figure 5B ).

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