Interestingly the Ras gene family within this pathway was predicted to be targeted by 14 of the top 16 highest detected miRNAs; this family of genes as a part of the Ras/Raf-1/MEK/ERK cascade is generally regarded as playing a highly significant role in cardiac hypertrophy, myocardial cell death and myocardial remodelling [151] .
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Distinctive profile of IsomiR expression and novel microRNAs in rat heart left ventricle.
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The sentences
Some of the more abundantly detected miRNAs showed some transmural difference that did not reach statistical significance across the three hearts.