Components of the interleukin-33/ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature.

However, this correlation did not reach statistical significance (p = 0.092; data not shown). 3.5 Endothelial cells but not cardiac myocytes, cardiac fibroblasts and smooth muscle cells predominantly express the IL-33 receptor ST2 and secrete sST2 In order to determine which cell types are a possible target for IL-33 or a source of sST2 in the human cardiovascular system we screened different cell types such as cardiac myocytes and fibroblasts and vascular smooth muscle cells and endothelial cells from various vascular beds for the expression of total ST2 mRNA, ST2L mRNA and sST2 mRNA as well as for the secretion of sST2 antigen.

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