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Proinflammatory Cytokines Stimulate Mitochondrial Superoxide Flashes in Articular Chondrocytes In Vitro and In Situ.

PLoS One · 2013 · PMC3686682 · PMID 23840469

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In contrast to the rapid flash response to proinflammatory cytokines, we observed only the trend of enhancement of flash activity in intact cartilage during the early phase of IL-1β or TNF-α challenge (0–30 min), but the increase did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.