RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation.

However, the two assays were able to identify a strong trend in the target gene panel and the trend was supported by the known biological roles of the control genes that affect glucose regulation in the liver, so data was sufficient to identify a subset of target genes that could be validated in subsequent experiments.

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