Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

Islets from mice heterozygous for the global Mll2 knockout also secreted more insulin at 2 mM glucose although this did not reach statistical significance, however they secreted significantly less insulin at 10 mM glucose compared to wild-type littermate controls and had lower fold change differences at 10 and 20 mM glucose.

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