Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens.

Structural analysis Volumetric measurements of the core and shell divisions of the NAc revealed a tendency for increased volume in both the subregions in animals exposed to CMS without antidepressant treatment that, however, failed to reach statistical significance (shell: P =0.612; core: P =0.339) ( Figures 2c and d ).

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