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Dose-dependent induction of murine Th1/Th2 responses to sheep red blood cells occurs in two steps: antigen presentation during second encounter is decisive.

PLoS One · 2013 · PMC3695941 · PMID 23840769

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In addition, the expression of Il10 and of Il4 increased 48 h after challenge; whereby the latter one did not reach statistical significance ( Fig. 4C ).

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