Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling.

Cardiac expression of proinflammatory cytokines ( Tnfα, Il6, and Il1b ) was enhanced in L‐NAME/Ang II‐treated control mice, which was attenuated in MyPHD2KO mice with borderline significance ( Figure 7 C).

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Our previous study suggests that Phd2 down‐regulation inhibits NF‐κB, 16 and NF‐κB activity showed a trend toward a decrease in PM from MyPHD2KO mice compared with control mice ( Figure 2 D).

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The second point is that the sample sizes are relatively small in the present study, which may explain why some statistical tests failed to reach significance.

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