New insights into mechanisms behind miscarriage.

BMC Med · 2013 · PMC3699442 · PMID 23803387

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highly significantno p-value reported

A recent meta-analysis including 16 studies found a highly significant increase in miscarriage rate in couples where the male partner had elevated levels of sperm DNA damage compared to those where the male partner had low levels of sperm DNA damage (risk ratio = 2.16 (1.54, 3.03, P <0.00001) [ 19 ].

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did not reach statistical significanceno p-value reported

However, this effect did not reach statistical significance and appropriately powered randomized controlled trials focusing on this patient subset are required to elucidate the clinical value of this therapeutic approach.

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