Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: results from the treatment of early aggressive rheumatoid arthritis trial.

Under that hypothesis, a positive relation would also be expected between the dosage of the minor allele at the rs886205 locus and MTX efficacy; however, the association with the DAS28 at 24 weeks observed in our study population was negative and did not reach statistical significance in the single marker analysis.

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