Patient considerations in the use of tapentadol for moderate to severe pain.

In bunionectomy trials 1 and 2, patients treated with tapentadol experienced less pruritus when compared with oxycodone IR; however, these differences did not reach statistical significance as seen in bunionectomy trial 2. 38 The most common side effects of tapentadol are nausea (30%), dizziness (24%), vomiting (18%), and somnolence (15%). 8 Higher satisfaction rates seen during the studies led to increased tolerability and lower discontinuation rates among the patients.

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