MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32.

We also performed supervised recurrence risk prediction analysis and identified a profile consisting of a subset of mRNAs (miRNA gene targets) that showed a strong trend in distinguishing good and poor prognosis tumors, although not as strongly as the miRNA levels themselves - probably as a result of a smaller sample size in this analysis ( n = 37, median RFS 28 months versus not-yet-reached, log rank P = 0.260; Figure 4C ).

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