IRF-1 responsiveness to IFN-γ predicts different cancer immune phenotypes.

However, the correlation of IRF-1 activation between controls and IFN- γ plus TNF- α -stimulated cells was not statistically significant although it maintained a positive trend ( P =0.27, ρ =0.30, Figure 1D ).

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The correlation between basal IRF-1 and the delta of IRF-1 activation after stimulation with IFN- γ , TNF- α and IFN- γ plus TNF- α did not reach statistical significance, suggesting that the IRF-1 activation was mainly dependent on the cytokine stimulation rather than on the basal level of IRF-1 activation ( Supplementary Figure S3 ).

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