Shared protein complex subunits contribute to explaining disrupted co-occurrence.

Compared to the expectation under random assignment, this is an over-representation in this category of 40% in yeast and 29% in human, which is modest, but because of the large numbers, highly significant (both p<1e-10).

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Although also a remarkable number of pairs with low pairwise similarity and triplet scores share complex membership or interact, there is a clear trend in all data sets for both measures to correlate with higher enrichments of interactions: The fields with the highest enrichment of co-complex pairs (orange and yellow) tend to be at the top (high pairwise similarity) and right-hand side (high triplet score) of the maps.

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