1 A ), mice treated with 10 μg/day leptin showed a trend toward glucose intolerance compared with nondiabetic controls and mice treated with 3 or 5 μg/day leptin.
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Leptin administration enhances islet transplant performance in diabetic mice.
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In contrast, the combination of leptin and 125 islets significantly lowered plasma glucose at 10 min, whereas there was a nonsignificant trend toward lower plasma glucose in mice treated with leptin and 50 islets.