Gene expression profiling identifies different sub-types of retinoblastoma.

It is also of interest that group 1 retinoblastomas showed an increased frequency of both post-laminar optic nerve invasion (PLONI, 6 out of 13, 46.1%) and deep choroid invasion (DCI, 8 out of 13, 61.5%) compared with group 2 (1 out of 6, 16.7% and 2 out of 8, 25.0% for PLONI and DCI respectively), although these differences did not reach statistical significance ( Table 1 ).

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