CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.

Detailed analyses of the gene expression network using publically-available ChIP-seq data ( http://genome.ucsc.edu/ENCODE/analyses ) revealed that there was a highly significant overrepresentation ( p = 3.8E−15) of MYC binding at the promoter regions among the positively correlated genes (29 of the 35 positively correlated genes), in relation to the negatively correlated genes (6 of the 67 genes) (Supporting Information Tables S3 and S4 ).

also in 132,142 other papers

Finally, using available p300 ChIP-seq data we also found a strong trend ( p = 0.055) towards coassociation of p300 with MYC at overlapping peaks at the promoters of positively correlated genes (66%), whereas MYC was less frequently associated with p300 at negatively correlated genes (25%) (Supporting Information Tables S3 and S4 ), in line with the presented molecular data ( Fig 5 ; Supporting Information Fig S5 ).

also in 5,725 other papers