Prevalence and phase variable expression status of two autotransporters, NalP and MspA, in carriage and disease isolates of Neisseria meningitidis.

In contrast, a highly significant difference ( p <0.0001) was detected in the frequency of mspA phase ON (tract length of 6, 9 or 12Cs) strains in the carriage versus invasive collections ( Table 6 ), with mspA being significantly more often ON in invasive isolates compared to carriage isolates (69.2% compared to 50.0%).

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The basis for this difference was apparent from our tract length analysis which showed that the mode tract length for MenB strains was 9Cs (phase ON), whilst for MenY strains the mode was 7Cs (phase OFF) ( Fig.

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