showed a trendp<0.0001
Results SPT showed a trend towards a decrease in the wheal surface area (mean in mm 2 B0 vs mean R1, p value; vs mean R2, p value): EW 97.5 vs 38.0, p<0.0001; vs 36.3, p<0.001; EY 33.5 vs 12.4 p<0.0001; vs 12.3, p=0.003; OVA 55.6 vs 19.1 p<0.0001; vs 17.3, p<0.001; OVM 109.6 vs 56.9, p=0.005; vs 44.8, p=0.000.