Association study of 167 candidate genes for schizophrenia selected by a multi-domain evidence-based prioritization algorithm and neurodevelopmental hypothesis.

PLoS One · 2013 · PMC3726675 · PMID 23922650

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0620

boldest claim

The sentences

nominally significantp<0.01actually significant

A number of genes, including PRKG1 , CNTN4 , and PRKCE , contained clusters of nominally significant SNPs (p<0.01): 17 SNPs in PRKG1 , 9 SNPs in CNTN4 , and 5 SNPs in PRKCE (see File S2 ).

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marginal significancep-value = 0.062so close (0.05 < p ≤ 0.1)

Another SNP, rs2043534 in NPAS2 , had marginal significance (p-value = 0.062).

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marginally significantno p-value reported

Of note, for the four SNPs that were significant or marginally significant in the meta-analysis of our SNPs ( Table 4 ), two were available in the PGC dataset including SNP rs2616591 that had a small p value (1.68×10 −3 ).

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