Causes of death and prognostic factors in multiple endocrine neoplasia type 1: a prospective study: comparison of 106 MEN1/Zollinger-Ellison syndrome patients with 1613 literature MEN1 patients with or without pancreatic endocrine tumors.

Medicine (Baltimore) · 2013 · PMC3727638 · PMID 23645327

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0980

boldest claim

The sentences

showed a trendp = 0.050actually significant

Almost reaching significance was the presence of PETs other than gastrinomas in patients with an MEN1-related death (47% vs 33%, p = 0.058), whereas thyroid disease showed a trend toward higher occurrence in patients with a non-MEN1-related death (0 vs 2.95%, p = 0.050).

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a trend toward significancep = 0.098so close (0.05 < p ≤ 0.1)

111 , 131 , 150 , 151 , 331 , 413 , 414 , 465 While our NIH MEN1/ZES series showed a trend toward significance for thymic carcinoid patients having a worse prognosis (p = 0.098), a number of factors likely contributed to it not reaching full significance as a prognostic factor.

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