The Q175 mouse model of Huntington's disease shows gene dosage- and age-related decline in circadian rhythms of activity and sleep.

Somewhat surprisingly, at 9 months, the Q175 Het and Hom mutants showed a trend towards better performance on the test than the WT controls ( F 2,22 = 2.935, P = 0.076), but this paradoxical finding was reversed by 12 months, where there was a gene dose-dependent decline in motor function ( Fig. 6A ; F 2,22 = 11.557, P <0.001) with post hoc comparisons revealing that Het mice performed worse than WT ( t = 2.419, P = 0.025) and Hom mice performed worse than both age-matched Het and WT mice ( vs Het t = 2.225, P = 0.0378; vs WT t = 4.806, P = 0.017).

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