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Hypoxia-ischemia or excitotoxin-induced tissue plasminogen activator- dependent gelatinase activation in mice neonate brain microvessels.

PLoS One · 2013 · PMC3735506 · PMID 23940734

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In PAI-1 −/− mice, global MMP-9 activity in gel was enhanced (+71%, p = 0.012, according to Student’ t test), while the modest increase in MMP-2 activity (+41%) did not reach statistical significance ( Fig. 5G,H ).

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