A cohort study of the impact of tooth loss and periodontal disease on respiratory events among COPD subjects: modulatory role of systemic biomarkers of inflammation.

Cox proportional hazards models using the periodontally healthy dentate group as the referent population in unadjusted models demonstrate a clear trend and a gradient with increasing periodontal disease severity increasing the hazards ratios (HR) from 1.90 (95% confidence interval: 1.28–2.83) to 2.22 (1.44–3.41) and 4.66 (3.21–6.78) for edentulism.

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In unadjusted models for GOLD stage I subjects there is an apparent trend of increasing hazard ratio associated with periodontal disease severity with the highest risk observed in the edentulous individuals [HR = 5.06 (2.60–9.85)].

also in 709 other papers