In the cortex of OLE-fed animals of both ages, Beclin 1 levels showed a trend towards an increase in wt mice and a significant increase in the Tg mice compared to the respective age-matched untreated animals, as exemplified in Fig. 4B for mice of 3.5 months of age.
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The polyphenol oleuropein aglycone protects TgCRND8 mice against Aß plaque pathology.
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