The reduced folate carrier (RFC-1) 80A>G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis.

Nutrients · 2013 · PMC3738987 · PMID 23857226

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showed a trendno p-value reported

A meta-analysis [ 15 ] of four genetic association studies [ 19 , 20 , 22 , 25 ], for a total of 354 MDS and 644 control mothers, was performed in 2009 to address the role of the RFC-1 80A>G polymorphism as a maternal risk factor for the birth of a child with DS, and showed a trend toward an association under the dominant model (GG + AG vs .

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