Cyclosporine A impairs the macrophage reverse cholesterol transport in mice by reducing sterol fecal excretion.

A clear trend for reduced cholesterol efflux was observed also in cells treated with CsA and exposed to micelles, although a statistical significance was not reached.

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However, in our experimental setting, CsA treatment did not produce significant alterations in plasma lipid levels: HDL-cholesterol levels were unchanged and only a small trend to increased non HDL-cholesterol was observed.

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