Multiple sclerosis: modulation of toll-like receptor (TLR) expression by interferon-β includes upregulation of TLR7 in plasmacytoid dendritic cells.

PLoS One · 2013 · PMC3741212 · PMID 23950974

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.1100

boldest claim

The sentences

almost reached statistical significancep = 0.053so close (0.05 < p ≤ 0.1)

Elevated TLR7 expression in pDCs of interferon-β-treated as compared to glatiramer acetate-treated patients almost reached statistical significance ( p = 0.053) as well.

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almost significantp = 0.06so close (0.05 < p ≤ 0.1)

A similar, almost significant ( p = 0.06), effect was also observed for tumor necrosis factor-α.

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showed a trendp = 0.11not close (p > 0.1)

In addition, macrophage inflammatory protein-1α showed a trend for upregulation in loxoribine-treated cells prestimulated with interferon-β ( p = 0.11).

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