Competence in Streptococcus pneumoniae is a response to an increasing mutational burden.

Although one isolate (lineage 5) in the mutX deletion group showed a trend toward loss of fitness in both assays—as would eventually be expected in a prolonged mutation accumulation experiment due to the random fixation of mildly deleterious mutations—this change was not significant when analyzed by ANOVA corrected for multiple comparisons.

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