Toll-like receptor-associated sequence variants and prostate cancer risk among men of African descent.

Although the two- and three-way models both had high CVC scores (≥ 80%), these models failed to reach statistical significance.

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In contrast, TOLLIP rs3168046 AA carriers had a marginally significant 42% reduction in PCA susceptibility (OR age-adjusted = 0.58; 95%CI = 0.35, 0.98).

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Upon stratification by study center, six of the 32 candidate TLR -associated SNPs were identified as modestly significant determinants of PCA risk after adjusting for age, as shown in Table 3 .

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