Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures.

For example, a significant increase in the quantity of α1(IX) collagen was detected in Comp T585M buffer 3 samples relative to wild type controls and a trend towards an increase in α1(IX) collagen extraction was observed in Comp DelD469 buffer 3 samples, but this did not reach statistical significance (WT spectra = 2 vs DelD469 spectra = 5; P = 0.072; data not shown).

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