Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis.

PLoS One · 2013 · PMC3745404 · PMID 23976977

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may be significantno p-value reported

It may be significant that evidence of a mutagenic activity in vivo has been obtained during Rib monotherapy [77] .

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did not reach statistical significanceno p-value reported

Only a minor reduction of mutant spectrum complexity (that did not reach statistical significance) was observed in the presence of guanosine at the two Rib concentrations tested ( Table 4 ).

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